abstract：:An increase in the incidence of cardiovascular disease has generally been observed in postmenopausal women, but there have been few studies of the association between menopausal state and atherosclerosis. In this study 294 premenopausal and 319 postmenopausal women aged 45 to 55 were examined radiographically for calc...

journal_title：BMJ (Clinical research ed.)

authors： Witteman JC,Grobbee DE,Kok FJ,Hofman A,Valkenburg HA

更新日期：1989-03-11 00:00:00

abstract：:The import of the HIV or AIDS epidemic for heterosexuals in Britain is difficult to evaluate at this stage. By June 1988, only 60 cases of heterosexually acquired AIDS are known, out of 1598 reported AIDS cases. Of these, only 6 women and 4 men presumably were infected in Britain, the rest abroad. But, judging from...

journal_title：BMJ (Clinical research ed.)

authors： Skegg DC

更新日期：1989-02-18 00:00:00

abstract：:An investigation was conducted to determine the vehicle of infection of an outbreak of food poisoning in a large metropolitan building early in 1988. A questionnaire was distributed to 700 people who had eaten in the building during the week of the outbreak, and attack rates for specific food were calculated. Food and...

journal_title：BMJ (Clinical research ed.)

authors： Mitchell E,O'Mahony M,Lynch D,Ward LR,Rowe B,Uttley A,Rogers T,Cunningham DG,Watson R

更新日期：1989-01-14 00:00:00

abstract：:To assess the prevalence of both diagnosed and undiagnosed diabetes mellitus in an area of predominantly Asian population the Coventry diabetes study is carrying out house to house screening for diabetes in people aged 20 and over in Foleshill, Coventry. In the first five of 12 areas to be studied 2130 of 2283 Asian (...

journal_title：BMJ (Clinical research ed.)

authors： Simmons D,Williams DR,Powell MJ

更新日期：1989-01-07 00:00:00

abstract：:The numbers of patients being admitted to hospital with aortic aneurysms have increased recently. A study was carried out to try to find out whether this was a true increase in incidence or whether it could be attributable to more accurate diagnosis and better surgical techniques. From analyses of routine statistics i...

journal_title：BMJ (Clinical research ed.)

authors： Fowkes FG,Macintyre CC,Ruckley CV

更新日期：1989-01-07 00:00:00

abstract：:Eleven euthyroid patients with severe Graves' eye disease were treated with intravenous methylprednisolone and followed up for six months or more by ophthalmological assessment, orbital computed tomography (CT), photographs, and antibody measurements. Papilloedema resolved in the single patient in whom it was present;...

journal_title：BMJ (Clinical research ed.)

authors： Kendall-Taylor P,Crombie AL,Stephenson AM,Hardwick M,Hall K

更新日期：1988-12-17 00:00:00

abstract：:Two patients with acute major, disabling cerebral infarction with presumed middle cerebral artery occlusion were treated with the clot specific thrombolytic agent tissue plasminogen activator roughly three and a half hours after the onset of symptoms. Both patients had a normal computed tomography (CT) scan before tre...

journal_title：BMJ (Clinical research ed.)

authors： Koudstaal PJ,Stibbe J,Vermeulen M

更新日期：1988-12-17 00:00:00

abstract：:Seventy five consecutive users of the Leeds disabled living foundation were surveyed. Two thirds of these users were at least moderately severely disabled. Forty eight of the 65 people (74%) who completed the questionnaire were recommended aids, and 33 had received some at the end of the survey. Only 10 of 28 people h...

journal_title：BMJ (Clinical research ed.)

authors： Chamberlain MA,Gallop J

更新日期：1988-12-10 00:00:00

abstract：STUDY OBJECTIVE:To assess effect of intravenous recombinant tissue type plasminogen activator on size of infarct, left ventricular function, and survival in acute myocardial infarction. DESIGN:Double blind, randomised, placebo controlled prospective trial of patients with acute myocardial infarction within five hours ...

journal_title：BMJ (Clinical research ed.)

authors： Van de Werf F,Arnold AE

更新日期：1988-11-26 00:00:00

abstract：:Fetomaternal haemorrhage was studied after 68 consecutive fetal intravascular transfusions performed in 20 patients with Rh isoimmunisation. alpha Fetoprotein concentration was assayed in maternal blood taken before, and immediately after each transfusion and three and 24 hours later. An increase of 50% or more in the...

journal_title：BMJ (Clinical research ed.)

authors： Nicolini U,Kochenour NK,Greco P,Letsky EA,Johnson RD,Contreras M,Rodeck CH

更新日期：1988-11-26 00:00:00

abstract：:The relations among parental reports of respiratory symptoms, bronchospasm measured after exercise, and the presence of visible fungal mould in the home was assessed in a population sample of 7 year old children (n = 873). Wheeze in the past year was the symptom most closely associated with reported dampness and parti...

journal_title：BMJ (Clinical research ed.)

authors： Strachan DP

更新日期：1988-11-12 00:00:00

abstract：STUDY OBJECTIVE:Comparison of four layer bandage system with traditional adhesive plaster bandaging in terms of (a) compression achieved and (b) healing of venous ulcers. DESIGN:Part of larger randomised trial of five different dressings. SETTING:Outpatient venous ulcer clinic in university hospital. PATIENTS:(a) Pr...

journal_title：BMJ (Clinical research ed.)

authors： Blair SD,Wright DD,Backhouse CM,Riddle E,McCollum CN

更新日期：1988-11-05 00:00:00

abstract：:A study was conducted (a) to assess the number of patients registered with a south London general practice who over 11 weeks referred themselves to an accident and emergency department, (b) to identify the characteristics of those patients, and (c) to determine their perceptions of the services and resources available...

journal_title：BMJ (Clinical research ed.)

authors： Singh S

更新日期：1988-11-05 00:00:00

abstract：:A randomised controlled trial of two management regimens was carried out in women patients over 65 years of age with hip fractures. Ninety seven patients were admitted to a designated orthopaedic geriatric unit and 125 to orthopaedic wards. No difference was observed in mortality, length of stay, or placement of patie...

journal_title：BMJ (Clinical research ed.)

authors： Gilchrist WJ,Newman RJ,Hamblen DL,Williams BO

更新日期：1988-10-29 00:00:00

abstract：:The place of balloon dilatation of the aortic valve in the treatment of calcific aortic stenosis is controversial. Thirty two patients (mean age 76) in whom valve replacement was contraindicated were followed up for three to 24 months (mean 8); 25 were in functional class III or IV according to the New York Heart Asso...

journal_title：BMJ (Clinical research ed.)

authors： Sprigings DC,Jackson G,Chambers JB,Monaghan MJ,Thomas SD,Meany TB,Jewitt DE

更新日期：1988-10-22 00:00:00

abstract：:When oxygen concentrators became available on form FP10 in 1985 the Department of Health and Social Security issued clear guidelines for their prescription for long term treatment. Reassessment of those patients prescribed a concentrator in one district showed that 29 out of 61 patients did not fulfil these criteria. ...

journal_title：BMJ (Clinical research ed.)

authors： Walshaw MJ,Lim R,Evans CC,Hind CR

更新日期：1988-10-22 00:00:00

abstract：:A study was performed to assess whether the existing differential capitation fees for general practitioners accurately assess differential workloads. Data from the third morbidity study in general practice were used to compare capitation fees with relative workload in differing age and sex groups. The population mix w...

journal_title：BMJ (Clinical research ed.)

authors： Fleming DM

更新日期：1988-10-15 00:00:00

abstract：:The development of a molecular genetics diagnostic service over a three year period was studied in a National Health Service region with a population of three million. Starting from a time when few diagnostic applications were possible, the number of disorders and the overall demand had grown rapidly. Conditions for w...

journal_title：BMJ (Clinical research ed.)

authors： Meredith AL,Upadhyaya M,Harper PS

更新日期：1988-10-01 00:00:00

abstract：:A total of 22,552 workers employed by the Atomic Weapons Establishment between 1951 and 1982 were followed up for an average of 18.6 years. Of the 3115 who died, 865 (28%) died of cancer. Mortality was 23% lower than the national average for all causes of death and 18% lower for cancer. These low rates were consistent...

journal_title：BMJ (Clinical research ed.)

authors： Beral V,Fraser P,Carpenter L,Booth M,Brown A,Rose G

更新日期：1988-09-24 00:00:00

abstract：:A random sample of 133 elderly patients who had an unplanned readmission to a district general hospital within 28 days of discharge from hospital was studied and compared with a matched control sample of patients who were not readmitted. The total group was drawn from all specialties in the hospital, and by interviewi...

journal_title：BMJ (Clinical research ed.)

authors： Williams EI,Fitton F

更新日期：1988-09-24 00:00:00

abstract：:There is strong circumstantial evidence that human papillomavirus is a cofactor in the development of cervical neoplasia. Systemic immunosuppression has also been implicated. A study was therefore carried out examining the relation between subtypes of human papillomavirus and local immunocompetent cells in the cervix....

journal_title：BMJ (Clinical research ed.)

authors： Hawthorn RJ,Murdoch JB,MacLean AB,MacKie RM

更新日期：1988-09-10 00:00:00

abstract：:Physicians need to evaluate clinical research critically, and determining the power of a study is an essential component of research evaluation. This report presents a graphical aid that permits rapid power determination for clinical trials with two groups. Power curves were developed for dichotomous outcomes by setti...

journal_title：BMJ (Clinical research ed.)

authors： Miller DK,Homan SM

更新日期：1988-09-10 00:00:00

abstract：:Several viral infections have been reported to result in more severe disease in pregnant than non-pregnant women, but the relative risks have not been well characterised. This has now been done for Lassa fever in a prospective study of 68 pregnant and 79 non-pregnant women who were admitted to hospital in Sierra Leone...

journal_title：BMJ (Clinical research ed.)

authors： Price ME,Fisher-Hoch SP,Craven RB,McCormick JB

更新日期：1988-09-03 00:00:00

abstract：:The results of the work of the Edinburgh Rehabilitation Medicine Service in one year were evaluated. Over 1400 new patients were seen, of whom 525 were in hospital at the time. Patients most often referred were those who had had cardiovascular accidents, back pain, lower limb amputations, and head injuries and those c...

journal_title：BMJ (Clinical research ed.)

authors： Roy CW,Arthurs Y,Hunter J,Parker S,McLaren A

更新日期：1988-09-03 00:00:00

abstract：:A total of 563 white primigravid patients at Raigmore Hospital, Inverness, were recruited in a prospective study to examine the association between maternal height, shoe size, and the outcome of labour. There was a significantly increased caesarean section rate in women of short stature but no association between mode...

journal_title：BMJ (Clinical research ed.)

authors： Mahmood TA,Campbell DM,Wilson AW

更新日期：1988-08-20 00:00:00

abstract：:The author is one of the medical advisers to the judge who led a government inquiry into allegations that an experimental research program at the National Women's Hospital in Auckland, New Zealand, to study the natural course of cervical carcinoma in situ had withheld conventional treatment from some patients. She ar...

journal_title：BMJ (Clinical research ed.)

authors： Paul C

更新日期：1988-08-20 00:00:00

abstract：:A study was carried out analysing the operation of a drug rationalisation programme in a central London teaching district that had evolved from experience over 17 years. Creation of a limited list of about 700 drugs had been achieved by local consensus. Drug selection was based on appraisal of efficacy, safety, and co...

journal_title：BMJ (Clinical research ed.)

authors： Baker JA,Lant AF,Sutters CA

更新日期：1988-08-13 00:00:00

abstract：:One hundred and two patients returned structured questionnaires sent to clinics for sickle cell disease in the United Kingdom in order to gain greater insight into the patients' perception of painful crises. Most patients who suffer pain crises experience a prodromal stage that should be investigated further to find o...

journal_title：BMJ (Clinical research ed.)

authors： Murray N,May A

更新日期：1988-08-13 00:00:00